Unmet Clinical Need

Neuroma prevention

76% of patients undergoing amputation experience chronic pain.¹

Treatment Challenge

Advanced surgical methods have shown promise, but fail to consistently prevent neuroma formation

When nerves are cut during amputation, they attempt to regenerate. Without a distal nerve to regenerate into, they often develop neuromas, causing phantom and residual limb pain for amputees. 

Successful treatment requires:

  • Protecting transected nerves
  • Preventing axonal escape
  • Eliminating neuroma formation

Preventing Neuromas

For amputees, no current treatment optimizes recovery and successfully prevents neuroma formation.

Reducing Pain

Neuromas are the leading cause of pain in amputees and surgeons seek solutions that consistently reduce pain.


Introducing the first and only fully absorbable in situ forming technology designed to protect transected nerves, prevent axonal escape and eliminate neuroma formation.

Pending FDA Clearance. Not available for sale.

Hydrogel designed to

Optimize Recovery & Prevent Neuroma Formation

Based on allay Nerve Cap mass loss at accelerated degradation (benchtop)²

Tailored absorption

Tulavi’s adaptive hydrogel remains in place during the most critical period of healing and then, through the process of hydrolysis, is fully absorbed in 8 months.


Across 6 preclinical studies, N>200, no neuroma formation present²

Fast & intuitive procedure

Direct Visualization

Transparent gel enables direct visualization to ensure procedural success. 


Activates upon delivery to enhance procedural confidence.


Without the need for sutures, procedural time is reduced, and granulomas are prevented.

  1. Mioton LM, et al. Targeted Muscle Reinnervation Improves Residual Limb Pain, Phantom Limb Pain, and Limb Function: A Prospective Study of 33 Major Limb Amputees. Clin Orthop Relat Res. 2020 Sep;478(9):2161-2167.
  2. Data on File at Tulavi Therapeutics.